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Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn.
Hasumi H, Baba M, Hasumi Y, Lang M, Huang Y, Oh HF, Matsuo M, Merino MJ, Yao M, Ito Y, Furuya M, Iribe Y, Kodama T, Southon E, Tessarollo L, Nagashima K, Haines DC, Linehan WM, Schmidt LS. Hasumi H, et al. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1624-31. doi: 10.1073/pnas.1419502112. Epub 2015 Mar 16. Proc Natl Acad Sci U S A. 2015. PMID: 25775561 Free PMC article.
Recent studies have revealed potential functions for Flcn in kidney; however, kidney-specific functions for Fnip1 and Fnip2 are unknown. ...We found that absolute Fnip2 mRNA copy number was low relative to Fnip1 in organs that showed phenotypes under …
Recent studies have revealed potential functions for Flcn in kidney; however, kidney-specific functions for Fnip1 and F …
Birt-Hogg-Dube syndrome: Clinical and molecular aspects of recently identified kidney cancer syndrome.
Hasumi H, Baba M, Hasumi Y, Furuya M, Yao M. Hasumi H, et al. Int J Urol. 2016 Mar;23(3):204-10. doi: 10.1111/iju.13015. Epub 2015 Nov 25. Int J Urol. 2016. PMID: 26608100 Review.
The folliculin gene (FLCN) that is responsible for Birt-Hogg-Dube syndrome was isolated as a novel tumor suppressor for kidney cancer. Recent studies using murine models for FLCN, a protein encoded by the FLCN gene, and its two binding partners, folliculin-interacting prot …
The folliculin gene (FLCN) that is responsible for Birt-Hogg-Dube syndrome was isolated as a novel tumor suppressor for kidney cancer …
Emerging Link between Tsc1 and FNIP Co-Chaperones of Hsp90 and Cancer.
Backe SJ, Sager RA, Meluni KA, Woodford MR, Bourboulia D, Mollapour M. Backe SJ, et al. Biomolecules. 2022 Jul 1;12(7):928. doi: 10.3390/biom12070928. Biomolecules. 2022. PMID: 35883484 Free PMC article. Review.
This chaperone system is essential for the stabilization and activation of many key signaling proteins. Recent identification of the co-chaperones FNIP1, FNIP2, and Tsc1 has broadened the spectrum of Hsp90 regulators. ...Given the broad cellular impact of Hsp90-dependent s …
This chaperone system is essential for the stabilization and activation of many key signaling proteins. Recent identification of the co-chap …
Identification and characterization of a novel folliculin-interacting protein FNIP2.
Hasumi H, Baba M, Hong SB, Hasumi Y, Huang Y, Yao M, Valera VA, Linehan WM, Schmidt LS. Hasumi H, et al. Gene. 2008 May 31;415(1-2):60-7. doi: 10.1016/j.gene.2008.02.022. Epub 2008 Mar 4. Gene. 2008. PMID: 18403135 Free PMC article.
These data taken together with our previous results that demonstrated FNIP1 binding to the C-terminus of FLCN suggest that FLCN tumor suppressor function may be facilitated by interactions with both FNIP1 and FNIP2 through its C-terminus. ...Differential expression …
These data taken together with our previous results that demonstrated FNIP1 binding to the C-terminus of FLCN suggest that FLCN tumor …
Interaction of folliculin (Birt-Hogg-Dube gene product) with a novel Fnip1-like (FnipL/Fnip2) protein.
Takagi Y, Kobayashi T, Shiono M, Wang L, Piao X, Sun G, Zhang D, Abe M, Hagiwara Y, Takahashi K, Hino O. Takagi Y, et al. Oncogene. 2008 Sep 11;27(40):5339-47. doi: 10.1038/onc.2008.261. Epub 2008 Jul 28. Oncogene. 2008. PMID: 18663353
The function of folliculin (Flcn), encoded by BHD, is totally unknown, although its interaction with Fnip1 has been reported. In this study, we identified a novel protein binding to Flcn, which is highly homologous to Fnip1, and which we named FnipL (recently report …
The function of folliculin (Flcn), encoded by BHD, is totally unknown, although its interaction with Fnip1 has been reported. In this …
The genetic basis of kidney cancer: a metabolic disease.
Linehan WM, Srinivasan R, Schmidt LS. Linehan WM, et al. Nat Rev Urol. 2010 May;7(5):277-85. doi: 10.1038/nrurol.2010.47. Nat Rev Urol. 2010. PMID: 20448661 Free PMC article. Review.
Kidney cancer is not a single disease but comprises a number of different types of cancer that occur in the kidney, each caused by a different gene with a different histology and clinical course that responds differently to therapy. Each of the seven known kidney …
Kidney cancer is not a single disease but comprises a number of different types of cancer that occur in the kidney, each cause …
The Role of Heat Shock Protein-90 in the Pathogenesis of Birt-Hogg-Dubé and Tuberous Sclerosis Complex Syndromes.
Woodford MR, Backe SJ, Sager RA, Bourboulia D, Bratslavsky G, Mollapour M. Woodford MR, et al. Urol Oncol. 2021 Jun;39(6):322-326. doi: 10.1016/j.urolonc.2020.03.016. Epub 2020 Apr 21. Urol Oncol. 2021. PMID: 32327294 Free PMC article. Review.
Birt-Hogg-Dube (BHD) and tuberous sclerosis (TS) syndromes share many clinical features. These two diseases display distinct histologic subtypes of renal tumors: chromophobe renal cell carcinoma and renal angiomyolipoma, respectively. ...The BHD-associated proteins FNIP …
Birt-Hogg-Dube (BHD) and tuberous sclerosis (TS) syndromes share many clinical features. These two diseases display distinct histolog …
Familial multiple discoid fibromas is linked to a locus on chromosome 5 including the FNIP1 gene.
van de Beek I, Glykofridis IE, Tanck MWT, Luijten MNH, Starink TM, Balk JA, Johannesma PC, Hennekam E, van den Hoff MJB, Gunst QD, Gille JJP, Polstra AM, Postmus PE, van Steensel MAM, Postma AV, Wolthuis RMF, Menko FH, Houweling AC, Waisfisz Q. van de Beek I, et al. J Hum Genet. 2023 Apr;68(4):273-279. doi: 10.1038/s10038-022-01113-1. Epub 2023 Jan 4. J Hum Genet. 2023. PMID: 36599954
We performed extensive clinical evaluations and genetic testing in ten families with FMDF. We identified a FNIP1 frameshift variant in nine families and genealogical studies showed common ancestry for eight families. ...Genome-wide linkage analysis showed that the locus on …
We performed extensive clinical evaluations and genetic testing in ten families with FMDF. We identified a FNIP1 frameshift variant i …
Nutrient-induced FNIP degradation by SCFβ-TRCP regulates FLCN complex localization and promotes renal cancer progression.
Nagashima K, Fukushima H, Shimizu K, Yamada A, Hidaka M, Hasumi H, Ikebe T, Fukumoto S, Okabe K, Inuzuka H. Nagashima K, et al. Oncotarget. 2017 Feb 7;8(6):9947-9960. doi: 10.18632/oncotarget.14221. Oncotarget. 2017. PMID: 28039480 Free PMC article.
Folliculin-interacting protein 1 and 2 (FNIP1 and FNIP2) play critical roles in preventing renal malignancy through their association with the tumor suppressor FLCN. ...However, the molecular mechanism functionally linking FNIP1/FNIP2 and FLCN remains largely elusiv …
Folliculin-interacting protein 1 and 2 (FNIP1 and FNIP2) play critical roles in preventing renal malignancy through their association …
11 results